Nicotinamide is a proprietary NAD+ precursor developed by Perpetua.Life® Biotech based on a an 80/20 blend of Mono/Riboside (LNR) which has been found to boost NAD+ level even higher than Riboside alone.

NAD+ is a compound found in every cell in your body and involved in many critical processes, including energy metabolism, DNA repair, and gene expression (22, 23).

NAD+ levels decline with age, and this decline is thought to be associated with accelerated physical decline and the onset of age-related diseases like Alzheimer’s (23).

Studies have shown that supplementing with NAD+ precursors like NR restores NAD+ levels and prevents age-related physical decline (24)

For example, a study in aging subjects demonstrated that supplementing orally with Nicotinamide Mono prevented age-associated genetic changes and improved energy metabolism, physical activity, and insulin sensitivity (24B).
A 2019 study in 12 men with an average age of 75 showed that supplementing with up to 1 gram of Nicotinamide daily for 21 days increased NAD+ levels in skeletal muscle and reduced levels of inflammatory proteins in the body (25).

Resveratrol is a polyphenol in grapes, berries, peanuts, and red wine that may promote longevity by activating certain genes called sirtuins. It has been shown to increase the lifespan of fruit flies, yeasts, and nematodes (42).

Effects of Resveratrol and other Polyphenols on Sirt1: Relevance to Brain Function During Aging (R4)

Resveratrol, an Nrf2 activator, alleviates aging-related progressive renal injury (R3)

Role of resveratrol in regulation of cellular defense systems against oxidative stress (R2).

Effect of resveratrol and pterostilbene on aging and longevity (R1).

Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a periodontitis model (R5).

Quercetin, caffeic acid and Resveratrol regulate circadian clock genes and aging-related genes in young and old human lung fibroblast cells (Q4).

Quercetin has antioxidant and anti-inflammatory effects which might help reduce inflammation, kill cancer cells, control blood sugar, and help prevent heart disease (Q1).

Quercetin in cancer prevention and therapy (Q2).

Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential
(F03).

Quercetin: A functional dietary flavonoid with potential chemo-preventive properties in colorectal cancer (Q3).

A preliminary investigation demonstrating the effect of quercetin on the expression of genes related to cell-cycle arrest, apoptosis and xenobiotic metabolism in human CO115 colon-adenocarcinoma cells using DNA microarray (Q4).

Quercetin, caffeic acid and Resveratrol regulate circadian clock genes and aging-related genes in young and old human lung fibroblast cells (Q4).

TMG has outstanding effects on controlling homocysteine levels in the blood. Homocysteine significantly increases around the middle stage of life, and it's linked to the development of heart disease and stroke.

In a breast cancer study, having more TMG in patients' diets was linked to fewer deaths from cancer [source].

In another study of more than 2800 lung cancer patients, high betaine intake was found to be protective against lung cancer [source].

A study including 193 senior citizens showed that an increase in TMG was linked to improvements in response time, memory, and brain function. People whose TMG levels went up the most also saw the most improvement in their memories [source].

Additionally, TMG is also being explored as treatment for other neurological disorders such as Alzheimer's disease [source].